Abstract The principal purpose of this study was to examine the effect of infrastructures of enterprise resource planning (ERP) lifecycle on the business performance (BP) of entrepreneurial companies. To this end, the relevant research literature and background were reviewed, and the model was designed based on two parts of dependent and independent variables in which, the effect of infrastructures of ERP lifecycle, as independent variables, (including customer relationship management (CRM), manufacturing resource planning (MRP), material procurement (MP), organizational and human resource management (OHRM), and business planning and control (BPC)) on the business performance, as the dependent variable, was examined in entrepreneurial companies. Accordingly, a standard questionnaire was designed based on a study conducted by Ahmad and colleagues (2019). The questionnaires were distributed among a selected sample that comprises managers and experts working in entrepreneurial companies in Tehran, Iran by using a convenient sampling method. The data collected from questionnaires were analyzed to test the research hypotheses. Results showed that all of the hypotheses were confirmed meaning that infrastructures of ERP lifecycle including CRM, MRP, MP, OHRM, BPC affected the business performance of entrepreneurial companies. According to findings, organizational and human resource management obtained the highest coefficient (0.59) while the lowest coefficient was associated with manufacturing planning management (0.48). Keywords: Infrastructure, Enterprise Resource Planning Lifecycle, Business Performance, Entrepreneurial Companies